Ontologies potentially involved in hemangiosarcoma pathogenesis and candidate biomarkers were identified. Top affected ontologies involved: (i) metabolism of bile acids, taurine, cholesterol, fatty acids and amino acids (ii) inflammation and oxidative stress and (iii) nicotinic cholinergic signaling.Ĭonclusions: The plasma metabolome was differentially regulated in polyvinyl chloride workers who developed hepatic hemangiosarcoma. The naturally occurring anti-angiogenic phenol, 4-hydroxybenzyl alcohol, was down-regulated 5-fold. Taurocholate, bradykinin and fibrin degradation product 2 were up-regulated by greater than 80-fold. But this is a relatively heavy dosage requiring 10-20 1000 mg pills/day. 60 metabolites were significantly increased and 44 were decreased vs. Eby recommends 10 to 20 grams of taurine/day combined with 4-6 grams of L-argenine to stop A-Fib. Random forest analysis had an 82% predictive accuracy for group classification. I started taking one 500mg pill every day in the morning to see how I felt.
I began experiementing with it two weeks ago. Mass spectroscopy identified 606 known metabolites. Basically, Taurine is an amino acid that seems to have this unusual ability to not only SIGNIFICANTLY control bouts of AFib, but also seems to target GABA receptors. Results: Cases and controls had similar demographics and routine liver biochemistries. Addition of clofibric acid or ciprofibrate had no effect on rat hepatocyte DNA synthesis whereas human hepatocytes responded with an inhibition of DNA synthesis. Although taurine is considered a conditionally essential nutrient for humans and is thought to play a key role in several human diseases, clinical studies evaluating the effects of taurine are limited.
Random forest and bioinformatic analyses were performed. One of the active ingredients often mentioned as a candidate for interactions with caffeine is the beta-amino acid, taurine. Methods: Plasma samples from polyvinyl chloride polymerization workers who developed hemangiosarcoma (cases, n = 15) and VC exposure-matched controls ( n = 17) underwent metabolomic analysis. NIAID What Scientists studying the body’s natural defenses against bacterial infection have identified a nutrient taurine that helps the gut recall prior infections and kill invading bacteria, such as Klebsiella pneumoniae ( Kpn ). The purpose of this study is to address these knowledge gaps through plasma metabolomics. Although VC is genotoxic, a more comprehensive mode of action has not been determined and diagnostic biomarkers have not been established. Taurine: its biological role and clinical implications Abstract More than simply cataloging the numerous experimental models in which taurine plays a modulating role, this discussion aims at stimulating further investigation of the potential clinical value of this abundant sulfur amino acid. Background: High-level occupational vinyl chloride (VC) exposures have been associated with hepatic hemangiosarcoma, which typically develops following a long latency period.
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